论文部分内容阅读
目的总结原发性乳腺恶性淋巴瘤临床特征及诊疗方法。方法回顾性分析9例原发性乳腺恶性淋巴瘤患者的临床资料。结果 9例患者中,6例患者术前行粗针穿刺活检,仅2例术前诊断为乳腺恶性淋巴瘤;9例患者均行手术治疗,其中6例行乳腺癌改良根治术,1例行单纯乳房切除术,2例因术前诊断为乳腺恶性淋巴瘤仅行肿瘤切除术;9例患者术后均给予环磷酰胺+阿霉素+长春新碱+泼尼松(CHOP)方案化疗,2例患者后续行局部放疗;9例患者初治后均获得完全缓解,随访期间死亡2例,分别死于脑转移和骨髓转移。结论手术切除是乳腺恶性淋巴瘤主要治疗手段,术后辅助化疗及局部放疗可提高治疗效果。
Objective To summarize the clinical features and diagnosis and treatment of primary breast malignant lymphoma. Methods The clinical data of 9 patients with primary malignant breast lymphoma were retrospectively analyzed. Results Of the 9 patients, 6 patients underwent gross needle biopsy before surgery, and only 2 patients had preoperative diagnosis of malignant lymphoma of breast. Nine patients underwent surgical treatment, of which 6 patients underwent modified radical mastectomy and 1 patient underwent radical mastectomy In the simple mastectomy, 2 cases underwent resection of the tumor due to preoperative diagnosis of malignant lymphoma of the breast. Nine patients were treated with cyclophosphamide plus doxorubicin plus vincristine plus prednisone (CHOP) Two patients were followed up with local radiotherapy. Nine patients achieved complete remission after initial treatment. Two patients died during follow-up and died of brain metastasis and bone marrow metastasis respectively. Conclusion Surgical resection is the main treatment of malignant lymphoma of the breast. Adjuvant chemotherapy and local radiotherapy can improve the therapeutic effect.