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目的探讨HIV/HCV共同感染者脂肪肝的发生率和独立危险因素分析。方法选取102例HIV/HCV共同感染者,通过彩超检查是否存在脂肪肝,分析所有患者的性别、感染途径、体质指数(BMI)、高效抗反转录病毒治疗(HAART)方案和持续时间、CD4+T淋巴细胞计数、空腹血糖、血脂、肝肾功能、HCV-RNA定量值和HCV-RNA阳性率,采用Logistic回归分析HIV/HCV共同感染者脂肪肝的独立危险因素。结果在102例HIV/HCV共同感染者中,21例(20.6%)存在脂肪肝。Logistic回归多变量分析发现脂肪肝的独立危险因素包括:高总胆固醇(TG)血症(OR=1.76,P=0.010)、低高密度脂蛋白(HDL)血症(OR=0.14,P=0.049)和HAART持续时间(OR=1.03,P=0.006);未发现患者的性别、感染途径、BMI、肝肾功能、HAART方案、CD4+T淋巴细胞计数、HCV-RNA定量值和HCV-RNA阳性率与脂肪肝的发生相关。结论 HIV/HCV共同感染者中脂肪肝的发生率为20.6%;高TG血症、低HDL血症和HAART治疗持续时间是脂肪肝发生的独立预测因素。
Objective To investigate the incidence and risk factors of fatty liver in HIV / HCV co-infected patients. Methods Totally 102 HIV / HCV co-infected patients were enrolled in this study. All patients were analyzed for sex, route of infection, body mass index (BMI), HAART regimen and duration, and CD4 + T lymphocyte count, fasting blood glucose, blood lipid, liver and kidney function, HCV-RNA quantitative value and HCV-RNA positive rate. Logistic regression was used to analyze the independent risk factors of fatty liver in HIV / HCV co-infected patients. Results In 102 HIV / HCV co-infected patients, fatty liver was found in 21 (20.6%) patients. Logistic regression multivariate analysis found that the independent risk factors of fatty liver include high serum total cholesterol (OR = 1.76, P = 0.010) and low HDL (OR = 0.14, P = 0.049 ) And HAART duration (OR = 1.03, P = 0.006). No gender, infection, BMI, liver and kidney function, HAART regimen, CD4 + T lymphocyte count, HCV-RNA quantification and HCV-RNA positive were found Rate and the occurrence of fatty liver related. Conclusions The incidence of fatty liver in HIV / HCV co-infected patients is 20.6%. Hypertriglyceridemia, hypoglycemia and HAART duration are independent predictors of fatty liver disease.