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作者将甲萘醌(维生素K_3;Menadione)用β-环糊精制成包合络合物,试图提高维生素K_3的稳定性、水溶性及生物活性。维生素K_3于β-环糊精水溶液中的溶解度,随β-环糊精浓度的增加而增大,由溶解度曲线推算,在包合物中,维生素K_3(客分子)与β-环糊精(主分子)的克分子比为1:1。维生素K_3在水中和在β-环糊精水溶液中的UV测定结果,亦支持此种论断。UV及圆二色散的结果并表明,在水溶液中,萘醌分子的苯环位于β-环糊精从配极(apolar)内的空穴中,醌基则伸出至β-环糊精以外而位于水中。~(13)C-NMR亦取得类似结果。但由于甲萘醌β-环糊精在水中溶解度低不足以作NMR测定,因而改用二甲基-β-
Menadione (Menadione) with β-cyclodextrin complex inclusion complex, trying to improve the stability of vitamin K_3, water-soluble and biological activity. The solubility of vitamin K_3 in β-cyclodextrin aqueous solution increased with the increase of β-cyclodextrin concentration. Calculated from the solubility curve, vitamin K_3 (guest molecule) and β-cyclodextrin ( Main molecule) molar ratio of 1: 1. The determination of vitamin K_3 in water and UV in β-cyclodextrin aqueous solution also supports this finding. The results of UV and circular dichroism show that in aqueous solution the benzene ring of the naphthoquinone molecule is located in a hole in the apolar of β-cyclodextrin and the quinone group is extended beyond the β-cyclodextrin In the water. ~ (13) C-NMR also obtained similar results. However, due to the low solubility of menaquinone β-cyclodextrin in water for NMR measurement, it was replaced by dimethyl-β-