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目的：探索家兔肝脏组织间插植内照射后放射损伤和修复的变化及其时间与剂量效应的关系。方法：将家兔分成４组：Ａ组１０ Ｇｙ、Ｂ组２０ Ｇｙ、Ｃ组３０ Ｇｙ、Ｄ组为对照组，观察内照射后１、２ 周及１、３、６ 月的组织形态学变化及照射后不同时间的肝脏放射毒性反应。结果：３ 个不同剂量组照射后不同时间ＷＢＣ、ＴＰ、ＧＰＴ、ＡＫＰ、ＴＢｉＬ与照射前比较无显著差异（Ｐ＞ ０．０５），照射后１～２周可见急性放射性肝炎改变；１～３月可见肝脏损伤性改变；３～６个月Ａ组肝脏损伤轻微，Ｃ组可见迟发性肝损伤恢复性改变。结论：单次３０ Ｇｙ以内局部内照射对肝脏无毒性反应；随着放射剂量加大局部损伤加重，照射后６个月：１０ Ｇｙ 组肝损伤基本恢复，３０ Ｇｙ 组出现典型的放射性肝纤维化改变。
OBJECTIVE: To explore the changes of radiation damage and repair and the relationship between time and dose effects in rabbits after liver irradiation. METHODS: The rabbits were divided into 4 groups: 10 Gy in group A, 20 Gy in group B, 30 Gy in group C, and 30 d in group D. The morphological changes at 1, 2 and 1, 3, and 6 months after internal irradiation were observed. And the radiation toxicity of the liver at different times after irradiation. Results: There were no significant differences in WBC, TP, GPT, AKP, and TBiL at different time after irradiation in three different dose groups (P> 0.05). Changes of acute radiation hepatitis were observed 1 to 2 weeks after irradiation; 1 to 3 Months showed changes of liver injury; 3 to 6 months of liver injury in group A was mild, and C group showed delayed recovery of liver injury. Conclusion: Local intra-irradiation within 30 Gy within a single time has no toxic reaction to the liver. With the increase of radiation dose, local injury worsens. Six months after irradiation, liver damage in 10 Gy group basically recovers, and typical radioactive liver fibrosis occurs in 30 Gy group. change.