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目的:探讨围产期缺氧性脑损伤患儿心肌酶的变化与脑损伤的主要危险因素、脑损伤程度的关系及其对脑损伤预后的影响。方法:选择2002年1月～2006年12月诊断为围产期缺氧性脑损伤(中重度)的105例作为患病组,根据有无神经系统后遗症分为预后不良组(A组)和痊愈组(B组);选择同期诊断为羊水吸入综合征的住院患儿105例为对照组(C组)。采用一维方差分析,对照研究心肌酶升高与出生前宫内窘迫、生后窒息、缺氧性脑损伤发病与否、生后抽搐或昏迷症状及与脑损伤后遗症的关系。结果:患病组与对照组比较各值差异均有统计学意义(P<0.05);A、B两组比较差异无统计学意义(P>0.05)。结论:心肌酶的升高水平与围产期缺氧性脑损伤的发病呈正相关,与脑损伤预后不良无关;心肌酶的升高与出生后窒息及重度脑损害症状显著相关,与产前宫内窘迫无显著相关性。
Objective: To investigate the relationship between the changes of myocardial enzymes and the risk factors of brain injury, the degree of brain injury and the prognosis of brain injury in children with perinatal hypoxic brain injury. Methods: A total of 105 patients diagnosed as perinatal hypoxic brain injury (moderate-severe) from January 2002 to December 2006 were selected as the diseased group. Patients with poor prognosis (group A) and (Group B). 105 hospitalized children diagnosed with amniotic fluid aspiration syndrome at the same period were selected as the control group (group C). One-way analysis of variance (ANOVA) was used to compare the relationship between elevated myocardial enzymes and intrauterine distress before birth, postnatal asphyxia, the incidence of hypoxic brain injury, convulsions or coma after birth, and sequelae of brain injury. Results: There was significant difference between the two groups (P <0.05). There was no significant difference between A and B groups (P> 0.05). Conclusions: The elevated level of myocardial enzymes is positively correlated with the incidence of perinatal hypoxic brain injury and has nothing to do with the poor prognosis of brain injury. The elevation of myocardial enzymes is significantly correlated with postnatal asphyxia and severe brain damage symptoms, No significant correlation between distress.