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目的 探讨胸腺瘤并重症肌无力 (MG)的诊断 ,治疗及预后的相关因素。方法 对 3 3例经过手术治疗的胸腺瘤合并MG患者的临床资料及随访资料进行分析。结果 术后总有效率为 75 8% ,5年及 10年生存率分别为 85 %及 78 7% ,Makaosa分期中Ⅰ期及Ⅱ期患者 5年及 10年生存率明显优于Ⅲ期及Ⅳ期患者 (P均小于 0 0 1)。结论 合理的围手术期处理 ,手术切除的彻底性 ,胸腺瘤Masaoka病理分期及出现重症肌无力的病程的长短对胸腺瘤合并MG的疗效及预后明显相关。
Objective To investigate the related factors of diagnosis, treatment and prognosis of thymoma and myasthenia gravis (MG). Methods Clinical data and follow-up data of 33 patients with thymoma complicated with MG treated by surgery were analyzed. Results The postoperative total effective rate was 75 8%, and the 5-year and 10-year survival rates were 85% and 78 7% respectively. The 5-year and 10-year survival rates of stage Ⅰ and stage Makaosa patients were significantly better than those of stage Ⅲ and Ⅳ The patients (P less than 0 0 1). Conclusion The reasonable perioperative management, the thoroughness of surgical resection, the stage of Masaoka thymoma and the duration of myasthenia gravis have a significant correlation with the curative effect and prognosis of thymoma combined with MG.