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5-脂氧合酶(5-lipoxygenase,5-LO)是催化花生四烯酸(AA)生成具有生物活性的白三烯(leukotrienes,LTs)的关键酶[1]。近年来研究发现,5-LO的调节在哮喘、炎症、过敏性鼻炎、组织缺血再灌注损伤、心血管疾病及部分恶性肿瘤等疾病的发生、发展过程中均有非常重要的意义[2]。因此,关于5-LO酶活性的调节和抑制剂的研发已成为一个热门课题,本文就其活性调节和抑制剂的研
5-lipoxygenase (5-LO) is a key enzyme that catalyzes the production of biologically active leukotrienes (LTs) by arachidonic acid (AA) [1]. Recent studies have found that the regulation of 5-LO plays an important role in the development and progression of asthma, inflammation, allergic rhinitis, tissue ischemia-reperfusion injury, cardiovascular diseases and some malignant tumors [2] . Therefore, the regulation of 5-LO enzyme activity and the development of inhibitors have become a hot topic. In this paper, its activity regulation and inhibitor research