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目的研制一种密闭式静脉配药装置,减少输液微粒对人体的潜在损害。方法在静脉配置中心和呼吸内科治疗室,分别采用2种方法配置同一种西林瓶类抗菌药物40份,实验组采用自主研发的一种密闭式静脉配药装置配药,对照组采用传统的注射器配药法配药,观察2个配药场所2组标本产生的不溶性微粒的数量。结果无论是静脉配置中心还是呼吸科治疗室的观察组标本产生的微粒≥10μm(个/m L)和≥25μm(个/m L)的数量,均符合我国2010版《药典》中静脉注射液的微粒值规定,且其产生的微粒数均明显少于在静配中心和呼吸科治疗室的对照组(P<0.01)。结论自研密闭式静脉配药装置在对配置西林瓶类药物方面能够有效减少输液微粒,增加患者输液安全。
Objective To develop a closed intravenous dispensing device to reduce the potential damage to the human body caused by transfusion particles. Methods In the venous center and respiratory medical treatment room, 40 kinds of the same vial antibacterial drugs were respectively allocated by two methods. The experimental group was self-developed a kind of closed intravenous dispensing device, while the control group was treated by the traditional syringe dispensing method Dispensing and observing the number of insoluble particles produced by two sets of samples in two pharmaceutical places. Results The number of microparticles ≥10μm (a / m L) and ≥25μm (a / m L) produced by the observation group in the venous or the respiratory treatment room all accorded with the Chinese version of Pharmacopoeia , And the number of particles produced was significantly less than that of the control group in the static center and respiratory treatment room (P <0.01). Conclusion Self-study of closed intravenous dispensing device in the allocation of vials can effectively reduce the infusion of particles, increase patient infusion safety.