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目的 观察国产甲型肝炎 (甲肝 )减毒活疫苗暴露后预防效果。方法 在河北正定某自然村甲型肝炎流行开始时 ,对该村小学所有学生采集血清 ,检测甲肝易感性 ,并给予接种一剂甲肝减毒活疫苗 [H2 株 ,滴度为 10 6 6 7组织培养半数感染量 (TCID50 ) ]。接种后 18天 (最短潜伏期 )与最后 1例甲肝病例发生后 4 0天 (最长潜伏期 )两次采集两组观察对象血清 ,观察两组感染与发病情况。结果 在接种后 18天以内及 18天至最后一病例发生后 4 0天 (流行结束 )两个观察期内 ,接种组与非接种组新感染率与罹患率均差异无显著意义 (P >0 0 5 )。结论 在本次流行中 ,未能发现甲型肝炎减毒活疫苗用于暴露后预防的效果 ,暴露后预防仍应以免疫球蛋白为主
Objective To observe the post-exposure prophylaxis effect of live attenuated hepatitis A (A) live vaccine in China. Methods At the beginning of the hepatitis A epidemic in a natural village in Zhengding, Hebei Province, serum was collected from all primary school students in this village to detect the susceptibility to hepatitis A and to inoculate a live attenuated attenuated hepatitis A vaccine [H2 strain with a titer of 10 6 6 7 tissue culture Half the amount of infection (TCID50)]. Two groups of sera from two observation groups were collected 18 days after vaccination (the shortest incubation period) and 40 days after the last case of hepatitis A (the longest incubation period), and the infection and incidence of the two groups were observed. Results There was no significant difference in new infection rate and attack rate between vaccinated group and non-vaccinated group within 18 days after vaccination and between 18 days and 40 days after the last case (epidemic end) 0 5). Conclusion In this epidemic, we failed to find out the effect of attenuated live attenuated Hepatitis A vaccine on post-exposure prophylaxis. Immunoglobulin should still be the mainstay of post-exposure prophylaxis