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目的通过可视化分析工具对万古霉素耐药研究情况进行可视化分析。方法以“vancomycin resistance”为主题词,利用智能检索引擎GoPubMed检索相关文献,并运用在线分析工具对万古霉素耐药的研究情况进行可视化分析。结果共检索到3 597篇有关万古霉素耐药的文献。从发表数量上看,可分为3个阶段:2000年以前的上升期,2000-2012年的平稳期,2012年以后的下降期。相对研究兴趣指数在2000年达到高峰,之后呈降低趋势。这些文献主要分布在欧洲、北美洲和亚洲,其中美国在万古霉素耐药方面发表的文献数量占首位,我国排第5位。美国的发表数量远高于我国,为10.5倍。在城市分布方面,波士顿居首位。刊载万古霉素耐药的杂志最多的是《Antimicrobial Agents Chemotherapy》,为309篇,占总量的8.6%。从作者文献产量角度分析,以COURVALIN P、JONES R、TENOVER F、DONSKEY C发表万古霉素耐药文章数量较多,位居前4,分别为52、42、36、31篇。结论尽管以“vancomycin resistance”为主题词检索Go Pub Med,我国学者发表的中文文章未被全部检索到,但把检索到的文献作为样本可部分反映万古霉素耐药研究的状况。通过分析发现由于人们对细菌耐药的重视并采取有效措施,使得万古霉素耐药好转,但仍需十分关注万古霉素耐药情况的发生。
Objective To visualize the vancomycin resistance study by means of visual analysis tools. Methods Using “vancomycin resistance” as the key word, the author searched the related literature by using GoPubMed, an intelligent search engine, and analyzed the research situation of vancomycin resistance by online analysis tools. Results A total of 3 597 articles on vancomycin resistance were retrieved. From the published quantity, it can be divided into three stages: the period before 2000, the period between 2000 and 2012, and the period after 2012. The relative research interest index peaked in 2000, after which it showed a decreasing trend. These documents are mainly distributed in Europe, North America and Asia. Among them, the United States has the largest number of published literature on vancomycin resistance and China ranks fifth. The number of U.S. publications is much higher than that of China, 10.5 times. Boston ranks first in urban distribution. The highest number of vancomycin-resistant magazines published was Antimicrobial Agents Chemotherapy, accounting for 309 articles, accounting for 8.6% of the total. From the perspective of the author’s literature production, the number of vancomycin-resistant articles published by COURVALIN P, JONES R, TENOVER F and DONSKEY C was the highest among the top 4, with 52, 42, 36 and 31 articles, respectively. Conclusion Although Chinese PubMed Med was searched with the title of “vancomycin resistance”, Chinese articles published by Chinese scholars were not completely retrieved. However, the retrieved documents may partly reflect the status of vancomycin resistance research. Through the analysis, it is found that vancomycin resistance is improved due to people’s attention to bacterial resistance and effective measures, but there is still a great need to pay attention to the occurrence of vancomycin resistance.