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东京女子医科大学教授镇目和夫、助教授高野加寿惠等将人生长激素(hGH)投予身体健康但身高较矮小的儿童(正常矮个)(参阅本刊1987年4月6日号),确认有促生长的作用。试验结果已于1987年6月3～5日在京都召开的日本内分泌学会上发表。高野等首先测定了35例正常矮个血中24小时内 GH 平均浓度。得知其中12例是每毫升含量在3纳克以下,1天的生理性的 GH 分泌量少的生长激素神经分泌机能障碍(GH neuro-secretory dysfunction,GHND,即生长激素分泌不全)。接着对这35例中愿意接受 hGH 的24例,以千克体重每天0.1国际单位的量,连续6个月投予 N 末端没有蛋氨酸的天然型 hGH。
Tokyo Metropolitan Women’s Medical University Professor Motuo Kazuhiro, Associate Professor Takano Kashio, etc. HGH is administered to healthy children but less tall children (normal dwarf) (see our publication April 6, 1987 issue) Promote the role of growth. The test results were published at the Japan Society of Endocrinology, Kyoto, June 3-5, 1987. Takaharu first determined the average concentration of GH within 24 hours of 35 normal short blood. Among them, 12 were GH neuro-secretory dysfunction (GHND), which has a physiological GH secretion per day of 3 ng or less and one day of physiological GH secretion. Next, 24 of the 35 patients who were willing to accept hGH were administered with natural hGH without N-terminal methionine for 6 consecutive months in an amount of 0.1 IU kg body weight per day.