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目的:研究白花丹参水提物对衰老小鼠学习、记忆障碍作用的影响。方法:小鼠灌胃给予白花丹参水提物,连续6周,利用Y型迷宫、跳台法和自主活动仪,观察白花丹参水提物对D-半乳糖所致学习记忆障碍的影响。结果:结果表明白花丹参水提物能明显改善D-半乳糖所致的学习记忆障碍的能力(P<0.05或P<0.01)。结论:白花丹参水提物对于衰老小鼠的学习、记忆障碍有明显的改善作用。
Objective: To study the effects of aqueous extract of Salvia miltiorrhiza on learning and memory impairment in senile mice. Methods: Mice were given gavage of aqueous extract of Salvia miltiorrhiza for 6 consecutive weeks. The effects of aqueous extract of Salvia miltiorrhiza on learning and memory dysfunction caused by D-galactose were observed by Y-maze, step-down method and autonomic activity meter. Results: The results showed that the water extract of Salvia miltiorrhiza can significantly improve the learning and memory impairment caused by D-galactose (P <0.05 or P <0.01). Conclusion: The aqueous extract of Salvia miltiorrhiza has a significant improvement on learning and memory impairment in aging mice.