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目的通过检测血清氧化物酶及尿微量白蛋白水平研究其对原发性高血压病人的颈动脉斑块形成的影响。方法分别检测350例原发性高血压患者及180例健康对照组血清氧化物酶及尿微量白蛋白水平,同时通过超声检测其颈动脉粥样硬化斑块形成率,研究血清氧化物酶及尿微量白蛋白水平对原发性高血压病人的颈动脉斑块形成的影响。结果350例原发性高血压受试对象经测定确认颈动脉存在硬化斑块共为102例,为29.14%。健康对照组180例中,共有颈动脉硬化斑块形成者12例,为6.67%。高血压组与正常健康对照组高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、总胆固醇(TC)、甘油三酯(TG)之间差异无统计学意义(P>0.05)。而高血压组血浆氧化物丙二醛(MDA)、髓过氧化物酶(MPO)及尿微量白蛋白(mALB)显著高于正常健康对照组,差异有统计学意义(P<0.05)。以尿微量白蛋白>19.0mg/L为尿微量白蛋白阳性,尿微量白蛋白阳性高血压组共有斑块形成62例,其颈动脉粥样硬化斑块形成率为39.2%,而尿微量白蛋白阴性高血压组有颈动脉斑块形成40例,其颈动脉粥样硬化斑块形成率为20.8%,而且其MDA、MPO浓度也显著低于尿微量白蛋白阳性组,差异有统计学意义(P<0.01)。结论高血清氧化物丙二醛、髓过氧化物酶及尿微量白蛋白可促进颈动脉粥样硬化斑块的形成。
Objective To investigate the effects of serum oxidase and urinary microalbumin on carotid plaque formation in patients with essential hypertension. Methods The levels of serum oxidase and urine microalbumin were detected in 350 patients with essential hypertension and 180 healthy controls respectively. At the same time, the carotid atherosclerosis plaque formation rate was measured by ultrasonography. The levels of serum oxidase and urine Effects of microalbumin on carotid plaque formation in patients with essential hypertension. Results A total of 102 carotid plaque samples were obtained from 350 subjects with essential hypertension who were confirmed as having a plaque score of 29.14%. Of the 180 healthy controls, 12 had carotid atherosclerotic plaques, accounting for 6.67%. There was no significant difference between HDL, LDL, TC, TG in hypertension group and normal control group (P> 0.05). However, the plasma levels of malondialdehyde (MDA), myeloperoxidase (MPO) and urinary albumin (mALB) in hypertension group were significantly higher than those in normal healthy group (P <0.05). Urine microalbumin> 19.0mg / L was urinary microalbumin-positive, urinary microalbumin-positive hypertension group formed 62 cases of common plaques, carotid atherosclerosis plaque formation rate of 39.2%, and urine micro-white 40 cases of carotid plaque were found in protein-negative hypertension group, the carotid atherosclerosis plaque formation rate was 20.8%, and the concentrations of MDA and MPO were also significantly lower than those in urine microalbumin-positive group, the difference was statistically significant (P <0.01). Conclusion High serum oxidized malondialdehyde, myeloperoxidase and urinary albumin can promote the formation of carotid atherosclerosis plaque.