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以３２ 例梗阻性黄疸病人为研究对象，３０ 例无黄疸的胆囊结石病人作为对照，观察梗阻性黄疸病人外周血补体、免疫球蛋白、Ｔ 细胞亚群、自然杀伤细胞及胆红素、胆汁酸、内毒素的变化，探讨梗阻性黄疸时影响机体免疫功能的因素，结果：良、恶性黄疸组血清总胆红素（ ＴＢＩＬ） 、直接胆红素（ＤＢＩＬ） 、总胆汁酸（ＴＢＡ） 、内毒素（ ＥＴ） 浓度均高于对照组（ Ｐ＜ ０ ．０１） ，而外周血Ｃ３ ，ＩｇＡ，ＣＤ＋４ ，ＣＤ＋８ ，ＮＫＣ 均明显低于对照组（ Ｐ＜ ０ ．０１ 或 Ｐ＜ ０ ．０５） ；随着黄疸时间延长，血清ＴＢＩＬ，ＤＢＩＬ 和ＴＢＡ 浓度逐渐升高（ Ｐ＜ ０ ．０１ 或 Ｐ＜ ０ ．０５） ，Ｃ３ ，ＣＤ＋４ 和ＣＤ＋８ 逐渐下降（ Ｐ＜ ０ ．０５） ；经相关分析和逐步回归分析（α＝ ０ ．０５） 得知，Ｃ３ 和ＣＤ＋８ 均与ＴＢＡ 呈负相关，ＣＤ＋４ 与ＴＢＩＬ 呈负相关。说明梗阻性黄疸病人血浆中胆红素、胆汁酸、内毒素可能为抑制机体免疫功能的主要因素，黄疸时间越长，抑制作用越明显
Thirty-two patients with obstructive jaundice were enrolled in this study. Thirty patients with cholecystolithiasis without jaundice were enrolled in this study. Peripheral blood complement, immunoglobulin, T cell subsets, natural killer cells and bilirubin were observed in patients with obstructive jaundice , Endotoxin changes in the obstructive jaundice affect the body’s immune function factors, the results: benign and malignant jaundice group serum total bilirubin (TBIL), direct bilirubin (DBIL), total bile acid (TBA), internal The levels of C3, IgA, CD + 4, CD + 8 and NKC in peripheral blood were significantly lower than those in the control group (P <0.01 or P <0.05). The serum concentrations of TBIL, DBIL and TBA gradually increased (P <0.01 or P <0.05), and the levels of C3, CD + 4 and CD + 8 decreased gradually with the prolongation of jaundice (P <0.05) Regression analysis (α = 0 .05) showed that C3 and D + 8 are negatively correlated with TBA, CD + 4 and TBIL negative correlation. Description obstructive jaundice in patients with plasma bilirubin, bile acids, endotoxin may be the main factor in the inhibition of immune function, the longer the jaundice, the more obvious inhibition