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慢性阻塞性肺病急性加重期（ AECOPD）和急性呼吸窘迫综合征（ ARDS）是呼吸道常见急症，由于两者以肺部感染作为加重病情发展的诱因，因此在抗感染的同时，基于炎症性肺损伤的病理生理机制，寻求更加快速、有效的治疗方法已受到越来越多的关注。促炎因子白细胞介素（IL）8在炎症反应中作用显著，参与多种炎性细胞的聚集活化。糖皮质激素虽然在治疗方面一直存在争议，但其强大的抗炎作用应用于临床治疗肺部疾病已有近半个世纪。该文主要探讨上述两种肺部疾病患者的IL－8表达，以及糖皮质激素在控制IL－8生成方面的作用。“,”Acute exacerbation of chronic obstructive pulmonary disease(AECOPD) and acute respiratory distress syndrome( ARDS) are common respiratory infectious diseases,for both of which pulmonary infection is the inducer of the deterioration,therefore besides anti-infection treatment,finding new faster and more effective treatments based on pathophysiological mechanisms of inflammatory lung injury has drawn more and more attention.Proinflammatory cytokines interleukin(IL) 8 has a significant role in the inflammatory reac-tion,involved in the aggregation and activation of a variety of inflammatory cells.Although there has been controversy in the treatment of glucocorticoid ,its powerful anti-inflammatory effect has been used in the clini-cal treatment of pulmonary disease for nearly half a century.Here mainly discusses the IL-8 expression in the two kinds of lung diseases patients,and the effect of glucocorticoid in controlling IL-8 formation.