1879年Chase首先提出各种金属可损坏牙齿,1932年Lain和Ullmann曾记述过微电流引起白斑。Ullmann曾报告在其检查的580例白斑中有3例发展为癌。Inoray和Bánóczy指出当有害的高电位被排除后,口腔粘膜疾病有显著改进。Frykholn和其同事研究了各种金属可能是发生扁平苔癣的病原因素。近来的研究提出,不但在口腔白斑而且在口腔扁平苔癣 In 1879, Chase first proposed that various metals can damage the teeth. In 1932, Lain and Ullmann described micro-currents that caused white spots. Ullmann has reported that 3 of the 580 white spots it examined developed cancer. Inoray and Bánóczy pointed out that when the harmful high potential was eliminated, there was a significant improvement in oral mucosal diseases. Frykholn and his colleagues studied various metals that may be the causative agent of lichen planus. Recent studies have proposed not only oral white spot but also oral lichen planus