目的 :建立一种适合临床影像设备进行实验研究的脑内出血动物模型。方法 :选用家猫 ,对尾状核、内囊或丘脑进行MRI三维定位后 ,采用立体定向技术注入自体动脉血。术后 3h行MRI扫描验证血肿 ,并于术后 72h对血肿及其周围组织行MRI评价。结果 :( 1 )尾状核头、内囊或丘脑的定位测量结果平均值 (mm)分别为 :前囟后距离 :5 .8、1 1 .1、1 1 .9;矢状缝右旁开距离 :5 .5、7.1、7.1 ;颅骨外板下垂直深度 :1 6.6、1 9.6、2 1 .5。 ( 2 )猫脑内注入自体血后均可形成局灶性大小、部位稳定的血肿 ,72h后血肿的MRT1WI信号强度明显增加 ,T2WI显示的血肿周围组织水肿区明显增大。结论 :MRI定位后建立的猫脑内出血模型 ,是较理想的适合于临床影像设备进行实验研究的脑内出血动物模型 Objective: To establish an animal model of intracerebral hemorrhage suitable for clinical imaging equipment. Methods: Domestic cats were used to inject autologous arterial blood by stereotactic technique after MRI three-dimensional localization of caudate nucleus, internal capsule or thalamus. The hematoma was confirmed by MRI scan 3h after operation and MRI was performed on the hematoma and its surrounding tissues at 72h after operation. Results: (1) The average value of the measurement of the location of the caudate nucleus, the internal capsule or the thalamus was (mm): the anterior bregma distance: 5.18,1 1 .1,1 1 .9; the right side of the sagittal suture Open distance: 5 .5, 7.1, 7.1; skull outer vertical depth: 1 6.6,1 9.6,2 1 .5. (2) After injection of autologous blood into the brain of the cat, focal and localized hematoma could be formed. The signal intensity of MRT1WI in the hematoma was significantly increased after 72 hours, and the edema area around the hematoma obviously increased on the T2WI. Conclusion: The intracerebral hemorrhage model established after MRI localization is an ideal animal model of intracerebral hemorrhage suitable for clinical imaging equipment.