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目的探讨腹膜炎患者应用利奈唑胺致血小板减少的危险因素。方法通过分析1例腹膜炎患者应用利奈唑胺治疗,患者发生血小板减少后,及时分析和判断血小板减少与利奈唑胺的相关性予以停药及相关对症治疗。结果和结论对于存在用药前血小板计数低、肾功能不全、肝功能异常、用药前白蛋白水平低、老龄、利奈唑胺用药时间大于14 d等危险因素的患者,在应用利奈唑胺时,应充分权衡利弊,如必须应用,应严密监测患者血常规等指标,一旦出现血小板减少,及时采取停药及对症处理措施,确保临床用药的安全性和有效性。
Objective To investigate the risk factors of thrombocytopenia induced by linezolid in patients with peritonitis. Methods One case of peritonitis was treated with linezolid, and the patients were treated with linezolid. The patients were analyzed for thrombocytopenia promptly and the correlation between them and linezolid was evaluated to stop the treatment and related symptomatic treatment. RESULTS AND CONCLUSIONS For patients with low risk of pre-treatment platelet count, renal insufficiency, abnormal liver function, low albumin level before treatment, age, and longer-term use of linezolid at 14 days, linezolid should be used Weigh the pros and cons, if necessary, should be closely monitored blood and other indicators of patients, in the event of thrombocytopenia, timely withdrawal and symptomatic treatment measures to ensure the safety and effectiveness of clinical medication.