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近来有报告表明,克霉唑是治疗库兴氏综合征 的有用药物,其机制可能是通过抑制该类病人的11β-羟化酶致皮质醇分泌减少,但对类固醇激素生物合成途径上的其他步骤也有抑制作用。 材料和方法:库兴氏病7例(女6例,男1例),库兴氏综合征女性1例。其中2例曾进行过不成功的垂体显微手术,1例成功地切除了垂体腺瘤,两年以后库兴氏病再次复发。两例分别有IDDM和NIDDM。4例有月经紊乱,1例有原发性闭经。所有病人的催乳素水平和甲状腺功能均正常。
Recently, it has been reported that clotrimazole is a useful drug for the treatment of Cushing’s syndrome and its mechanism may be through inhibition of 11β-hydroxylase-induced cortisol secretion reduction in these patients, but the steroid hormone biosynthesis pathway on other Steps also have inhibitory effect. Materials and Methods: Seven patients (6 males and 1 male) with Cushing’s disease and 1 female with Cushing’s syndrome. Two of the patients had unsuccessful hypophyseal microsurgery, one had a successful resection of the pituitary adenoma, and two years later, Cushing’s disease relapsed again. Two cases were IDDM and NIDDM respectively. 4 cases of menstrual disorders, 1 case of primary amenorrhea. Prolactin levels and thyroid function were normal in all patients.