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本文介绍6例(男女各3,年龄为8.4～13.3岁)急性肾小球肾炎重症患者,经用1周支持疗法后肾功能严重损害,急剧变坏或无改善。肾活检为增殖性肾小球肾炎伴有肾小球坏死及/或上应新月体形成。用血浆纤维蛋白原凝胶色谱法及一系列凝血检查证实有明显持续性的血管内凝血。肾活检后2～3天起服硫唑嘌呤2毫克/公斤,每早1次。同时用肝素100单位/公斤静脉推注后滴注,维持凝血时间于25至30分钟。3天后开始口服抗凝剂苯茚二酮约1毫克/公斤,每日2次,以后改变剂
This article describes 6 patients (3 males and 3 age 8.4 to 13.3 years) with severe acute glomerulonephritis. After one week of supportive therapy, their renal function is severely impaired, abruptly worsened, or not improved. Renal biopsy is associated with proliferative glomerulonephritis with glomerular necrosis and / or crescent formation. Plasma fibrinogen gel chromatography and a series of coagulation tests have demonstrated significant and sustained intravascular coagulation. 2 to 3 days after renal biopsy served azathioprine 2 mg / kg, 1 time per day. At the same time with heparin 100 units / kg intravenous infusion after instillation, to maintain clotting time in 25 to 30 minutes. 3 days after the beginning of oral anticoagulant phenylindadine about 1 mg / kg, 2 times a day, later change agent