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目的： 探讨ｒａｓ、ｃｅｒｂＢ２、ｐ５３ 基因产物ｐ２１ 、ｐ１８５ 、ｐ５３ 蛋白表达对卵巢浆液性肿瘤中良性瘤、交界性瘤和癌的鉴别诊断价值。方法： 采用ＬＳＡＢ免疫组化法。结果：３ 种蛋白在良性瘤、交界性瘤和癌中的单一表达均呈递增趋势，差异显著；联合表达，２ 种以上蛋白同时阳性率后两组高于良性瘤组，差异显著，Ｐ＜ ０００５ ；３ 种蛋白同时阳性率癌组高于前两组，差异显著，Ｐ＜ ００５ 。结论：３ 种蛋白的表达可以作为卵巢浆液性肿瘤中良性瘤、交界性瘤和癌的鉴别诊断的客观指标。
Objective: To investigate the ras, c erbB 2, p53 gene products p21, p185, p53 protein expression of ovarian serous tumors in the differential diagnosis of benign tumors, borderline tumors and cancer. Methods: LSAB immunohistochemistry. Results: The single expression of all three proteins in benign tumors, borderline tumors and carcinomas showed an increasing trend with significant difference. The positive expression rate of the two proteins in the two groups was significantly higher than that in benign tumors (P < 0005; The positive rates of the three proteins in cancer group were higher than those in the former two groups, with significant difference (P <005). Conclusion: The expression of three proteins can be used as an objective indicator in the differential diagnosis of benign tumors, borderline tumors and carcinomas in ovarian serous tumors.