论文部分内容阅读
1,2-二甲乙烯磺酸(EDS)对成年雄性大鼠的抗不育作用已有研究,一次注射EDS后对成年大鼠睾丸间质细胞具有特殊细胞毒性作用,但对未成年大鼠的毒性作用则研究甚少。实验选用未断乳的新生Wistar雄性大鼠,于出生后第5至16天连续12天皮下注射EDS50 mg/kg,观察睾丸的形态学变化。对照组皮下注射等量的溶剂2 ml/kg。动物分别于出生后第6、11、14、17、28、35、49、63和108天分
The anti-infertility effects of 1,2-dimethylenesulfonic acid (EDS) on adult male rats have been studied. One injection of EDS has a special cytotoxic effect on adult rat testicular stromal cells. However, The toxic effects are less studied. In this study, weaning neonatal Wistar male rats were injected subcutaneously with EDS50 mg / kg on the 5th to 16th day after birth to observe the morphological changes of testis. Control group subcutaneous injection of the same amount of solvent 2 ml / kg. Animals were dosed on days 6, 11, 14, 17, 28, 35, 49, 63 and 108, respectively