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目的 :探讨急性心肌梗死 (AMI)患者发病后 1个月内心肌纤维化指标的变化规律及其临床意义。方法 :采用放射免疫分析法测定 42例急性心肌梗死发病后第 2、7、14、2 8天血清Ⅰ型前胶原羧基端肽 (PⅠCP)和Ⅲ型前胶原氨基端肽 (PⅢNP)含量。结果 :AMI发病后第 7、14、2 8天的血清PⅠCP和PⅢNP水平与对照组比较均明显升高 (P >0 .0 0 1) ,发病后第 7、14、2 8天的血清PⅠCP及PⅢNP维持在较高水平 ,互相比较差异无显著性 (P >0 .0 5 )。结论 :AMI患者血清PⅠCP和PⅢNP含量明显升高并持续 1个月以上 ,反映AMI后心肌间质胶原的合成增加 ,致心肌过度纤维化
Objective: To investigate the changes and clinical significance of myocardial fibrosis in patients with acute myocardial infarction (AMI) within one month after onset. Methods: Radioimmunoassay was used to determine the serum levels of serum type Ⅰ procollagen carboxy terminal peptide (PⅠCP) and type Ⅲ procollagen aminoterotide (PⅢNP) in 42 patients with acute myocardial infarction at 2, 7, 14 and 28 days after the onset of acute myocardial infarction. Results: The levels of serum PⅠCP and PⅢNP on the 7th, 14th and 28th day after AMI were significantly higher than those in the control group (P> 0.05). The serum PⅠCP And PⅢNP maintained at a high level, no significant difference compared with each other (P> 0.05). CONCLUSIONS: The levels of serum PⅠCP and PⅢNP in patients with AMI were significantly elevated for more than 1 month, reflecting the increased synthesis of myocardial interstitial collagen after AMI and the excessive myocardial fibrosis