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非早期的糖尿病肾病的特征是肾小球系膜扩张，小结形成，肾小球基底膜增厚，伴随输入和输出小动脉透明变性以及间质的纤维化。Ⅳ型胶原是肾基底膜和肾小球膜基质的主要成份。本研究测定了糖尿病患者血清Ⅳ型胶原的水平与尿白蛋白程度，阐述在糖尿病肾病患者中测定血清Ⅳ型胶原
Non-early diabetic nephropathy is characterized by mesangial expansion, formation of nodules, thickening of the glomerular basement membrane, transparent degeneration of input and output arterioles, and interstitial fibrosis. Type IV collagen is the main component of the renal basement membrane and mesangial matrix. This study measured the level of serum type Ⅳ collagen in patients with diabetes and urinary albumin levels, described in patients with diabetic nephropathy serum type Ⅳ collagen