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目的:探讨急危重症患者SIRS、MODS、MOF的临床发展过程及相关影响因素。方法:对ICU477例患者病历复习,对SIRS、MODS、MOF进行回顾性诊断,并行相关统计学处理。结果:不同病因SIRS发生率无明显差异(x~2=6.58,P>0.05),MODS及MOF发生率有显著性差异(x~2=99.62,P<0.00l;x~2=23.92,P<0.001),MOF发生后病死率无明显差异(x~2=1.68,P>0.05),器官衰竭数与病死率呈明显正相关。结论:急危重症患者发生SIRS、MODS、MOF虽然有其固有的病理机制,但仍受病因、患者基础状态、干预性治疗效果以及受损器官间相互作用等多因素影响。因此,对MOF应从多方位进行研究。
Objective: To investigate the clinical development of SIRS, MODS and MOF in critically ill patients and related factors. Methods: The clinical records of ICU477 patients were reviewed, and the diagnosis of SIRS, MODS and MOF were retrospectively analyzed and related statistical analysis was performed. Results: There was no significant difference in the incidence of SIRS between different etiologies (x ~ 2 = 6.58, P> 0.05). The incidence of MODS and MOF were significantly different (x ~ 2 = 99.62, P <0.00l; <0.001). There was no significant difference in mortality after MOF (x ~ 2 = 1.68, P> 0.05). There was a significant positive correlation between the number of organ failure and the case fatality rate. Conclusion: SIRS, MODS and MOF in acute critically ill patients have their own pathological mechanism, but they are still affected by many factors such as the etiology, the basic state of patients, the effect of interventional therapy and the interaction between damaged organs. Therefore, MOF should be studied in many aspects.