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目的研究病毒性脑炎患儿脑脊液白细胞介素-6(IL-6)和血清C反应蛋白(CRP)的变化及其临床意义。方法用双抗体夹心酶标免疫分析法测定病毒性脑炎脑脊液(CSF)IL-6和血清CRP的水平,并分析IL-6和CRP的相关性。结果轻重度病毒性脑炎脑脊液(CSF)IL-6和血清CRP水平均有升高,其水平与病毒性脑炎的严重程度显著相关(P<0.01),并且病毒性脑炎脑脊液(CSF)IL-6和血清CRP含量之间呈正相关(P<0.05)。结论脑脊液(CSF)IL-6和血清CRP是评价病毒性脑炎早期炎症损伤程度的重要生化指标,其含量变化与伤情严重程度密切相关,通过对其动态观察可及时判断病毒性脑炎的严重程度及预后。
Objective To study the changes of cerebrospinal fluid interleukin-6 (IL-6) and serum C-reactive protein (CRP) in children with viral encephalitis and their clinical significance. Methods The levels of interleukin-6 (IL-6) and serum CRP in cerebrospinal fluid (CSF) of patients with viral encephalitis were determined by double antibody sandwich enzyme immunoassay. The correlation between IL-6 and CRP was analyzed. Results The level of IL-6 and serum CRP in cerebrospinal fluid (CSF) of patients with severe and severe encephalitis both increased significantly (P <0.01), and the level of CSF was significantly correlated with the severity of viral encephalitis There was a positive correlation between IL-6 and serum CRP (P <0.05). Conclusion Cerebrospinal fluid (CSF) IL-6 and serum CRP are important biochemical indexes to evaluate the degree of early inflammatory damage of viral encephalitis. The content of CSF IL-6 and serum CRP are closely related to the severity of the disease. Judgment of viral encephalitis Severity and prognosis.