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目的探讨宫颈腺样基底细胞癌的临床病理学特点及其鉴别诊断。方法对2例宫颈腺样基底细胞癌临床资料、组织形态、免疫组织化学、HPV分型进行综合分析。结果宫颈腺样基底细胞癌多见于老年妇女,临床无明显阳性体征。组织形态特征为小类圆形细胞巢,由温和一致的基底样细胞组成,巢周栅栏状排列,部分巢中央有腺样结构,表面常伴随宫颈上皮内瘤变。免疫组化CK5/6和P63阳性表达,但巢中央腺样结构区阴性。CK7阴性。HPV多为16型阳性。结论宫颈腺样基底细胞癌与HPV感染相关,病理组织学具有特征性,必要时辅以免疫组化,可与其他宫颈肿瘤鉴别。
Objective To investigate the clinicopathological features and differential diagnosis of cervical adenoid-like basal cell carcinoma. Methods The clinical data, histological morphology, immunohistochemistry and HPV typing of 2 cases of cervical adenoid-like basal cell carcinoma were analyzed comprehensively. Results Cervical adenoid-like basal cell carcinoma was more common in elderly women and had no clinically significant positive signs. Tissue morphological characteristics of small round cell nests, composed of moderately consistent basal-like cells, nests arranged in the shape of fence, part of the nest central adenoid structure, the surface often accompanied by cervical intraepithelial neoplasia. Immunohistochemical CK5 / 6 and P63 positive expression, but the nest central adenoid-like structure area negative. CK7 negative. HPV is mostly 16 positive. Conclusions Cervical adenoid-like basal cell carcinoma is associated with HPV infection. The histopathology is characteristic and supplemented by immunohistochemistry when necessary, which can be differentiated from other cervical tumors.