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目的:观察相同日剂量加替沙星单次与分2次静脉滴注治疗泌尿系感染的临床疗效,探索加替沙星合理给药方案。方法:将103例泌尿系感染患者随机分为A、B组,A组采用加替沙星0·4g溶于生理盐水100mL中,静脉滴注,qd;B组采用加替沙星0·2g溶于生理盐水100mL中,静脉滴注,bid。2组疗程均为7～10d,疗程结束时观察2组有效率及细菌清除率。结果:A、B组有效率分别为94·12%、80·77%(P<0·05),细菌清除率分别为91·11%、80·43%(P<0·05),不良反应发生率分别为7·84%、5·77%(P>0·05)。结论:加替沙星单次使用临床疗效显著优于分2次使用。
OBJECTIVE: To observe the clinical efficacy of gatifloxacin single or divided intravenous infusion in the same daily dose of gatifloxacin for the treatment of urinary tract infection, and to explore the reasonable dosage regimen of gatifloxacin. Methods: 103 cases of urinary tract infection were randomly divided into A, B group, A group gatifloxacin 0.4 g dissolved in 100 ml of normal saline, intravenous drip, qd; B group gatifloxacin 0.2 g Dissolved in saline 100mL, intravenous infusion, bid. The two groups of treatment were 7 ~ 10d, the end of the treatment group observed two groups and bacterial clearance rate. Results: The effective rates of group A and group B were 94.12% and 80.77% (P <0.05), the bacterial clearance rates were 91.11% and 80.43% (P <0.05) Response rates were 7 · 84%, 5 · 77% (P> 0.05). Conclusion: Gatifloxacin single-use clinical efficacy was significantly better than 2 times.