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探讨细胞周期素Ｅ（ＣｙｃｌｉｎＥ）在胃癌发生发展中的作用，采用免疫组化染色法检测了９５例胃癌标本。结果显示，正常胃上皮细胞不表达ＣｙｃｌｉｎＥ，而４０．０％（３８／９５）的胃癌细胞则呈阳性反应。分化癌ＣｙｃｌｉｎＥ的异常表达较显著（Ｐ＜０．０５）。粘膜内癌无强表达，且弱表达率也很低（Ｐ＜０．０５）。发生血行转移时强表达显著（Ｐ＜０．０１）。强表达患者术后生存期和５年生存率降低（Ｐ＜０．０５）。提示ＣｙｃｌｉｎＥ的异常表达可能参与了胃癌的发生与发展过程
To investigate the role of cyclin E in the development of gastric cancer, immunohistochemical staining was used to detect 95 gastric cancer specimens. The results showed that normal gastric epithelial cells did not express CyclinE, whereas 40.0% (38/95) of gastric cancer cells showed a positive reaction. The abnormal expression of CyclinE in differentiated carcinoma was significant (P<0.05). There was no strong expression of intramucosal carcinoma, and the weak expression rate was also very low (P<0.05). Significant expression was observed when blood was transferred (P<0.01). The postoperative survival and 5-year survival rate were significantly lower in patients with strong expression (P<0.05). It is suggested that the abnormal expression of CyclinE may be involved in the occurrence and development of gastric cancer