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本文综合多项研究比较α和β阻滞剂对高血压病人的脂代谢效果。 6项研究(包括6个治疗组共1647例高血压病人)评价了非选择性β阻滞剂普萘洛尔和噻吗洛尔对血脂的影响。结果表明,这些药物减少高密度脂蛋白胆固醇(HDL-ch)水平4.5～19.8%(平均减少12.8%),总血清甘油三酯(TG)升高14.7～51.3%(平均增加31.2%)。6个治疗组中,脂代谢改变有统计学意义(p<0.05)者,HDL-ch共5组,TG共6组。 7项研究(包括10个治疗组共290例高血压病人,治疗期2.5～12个月)评价了选择
This article synthesizes a number of studies comparing the effects of alpha and beta blockers on lipid metabolism in hypertensive patients. Six studies, including 1647 hypertensive patients in six treatment groups, evaluated the effects of propranolol and timolol, a non-selective beta blocker, on blood lipids. The results showed that these drugs reduced HDL-cholesterol levels by 4.5-19.8% (an average reduction of 12.8%) and total serum triglycerides (TG) by 14.7-51.3% (an average increase of 31.2%). Six of the six treatment groups, lipid metabolism was statistically significant (p <0.05), HDL-ch total of 5 groups, TG total of 6 groups. Seven studies (including 290 hypertensive patients in 10 treatment groups with a treatment duration of 2.5 to 12 months) evaluated the choice