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造血干细胞是生成血细胞的原始细胞,目前已知造血干细胞是造血组织中具有自我复制和分化能力的一类细胞。造血干细胞的研究在日本受到广泛重视,成为细胞生物学、分子生物学和血液学研究的重要课题。高久曾指出:若不了解以造血干细胞为中心的血细胞分化的新知识,进行现代血液学问题的讨论是有困难的。一、脾囊落形成单位(CFU—S)和混合集落形成单位(CFU—mix) 1961年Till和McCulloch进行造血细胞对放射线敏感性的研究,发现小鼠经致死剂量
Hematopoietic stem cells are primitive cells that produce blood cells. It is known that hematopoietic stem cells are a type of cells that have the ability to self-replicate and differentiate in hematopoietic tissues. Hematopoietic stem cell research in Japan has received widespread attention as an important topic in cell biology, molecular biology and hematology. It has long been pointed out that there is difficulty in discussing modern hematology issues without understanding new knowledge of hematopoietic cell differentiation centered on hematopoietic stem cells. First, the spleen capsule forming units (CFU-S) and mixed colony-forming units (CFU-mix) 1961 Till and McCulloch hematopoietic cells on radiosensitivity studies found that mice lethal dose