论文部分内容阅读
在Hansch分析法中,最常用的理化参数是疏水参数、电子参数与立体参数。由于有些药物的生物活性基本上只与疏水参数有关,因此对疏水参数的应用和研究引起了普遍的兴趣。疏水参数是对药物疏水性自由能变化的一种量度,主要反映药物进入生物体后在生物膜和体液之间的分配、转运以及与疏水蛋白受体间结合时疏水自由能变化的情况。在Hansch
In Hansch analysis, the most commonly used physical and chemical parameters are hydrophobic parameters, electronic parameters and stereo parameters. Since the biological activity of some drugs is basically only related to the hydrophobic parameters, the application and research of hydrophobic parameters have aroused general interest. Hydrophobic parameters are a measure of the change in hydrophobic free energy of a drug and mainly reflect changes in the hydrophobic free energy of the drug when it enters the organism and then distributes and transfers between the biofilm and the body fluid as well as when bound to the hydrophobin receptor. In Hansch