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目的探讨将移植胚胎数由3枚减为2枚对体外受精临床妊娠率和多胎发生率的影响。方法选择2002年8月至2004年8月在南京大学医学院附属鼓楼医院生殖医学中心进行体外受精,年龄≤35岁的妇女共424个周期,其中2胚胎组235个周期,3胚胎组189个周期。比较两组胚胎种植率、临床妊娠率和多胎发生率。结果2胚胎组和3胚胎组胚胎种植率与临床妊娠率差异无显著性意义(40.85%和40.92%,59.57%和67.20%,P>0.05)。2胚胎组单胎妊娠率明显高于3胚胎组(64.29%和40.16%,P<0.01),而三胎妊娠率明显降低(1.43%和22.83%,P<0.01),但两组双胎妊娠率差异无显著性意义(34.29%和37.01%,P>0.05)。结论对年轻妇女,胚胎移植数由3枚减为2枚,并不降低体外受精妊娠率。但明显降低了多胎妊娠特别是高序多胎妊娠的发生率。
Objective To investigate the effects of the number of embryos transferred from 3 to 2 on clinical pregnancy rate and multiple birth rate in vitro fertilization. Methods A total of 424 cycles of ≤35 years of age were enrolled in this study from August 2002 to August 2004 at Gulou Hospital Affiliated to Reproductive Medicine Center, Nanjing University Medical School. There were 235 cycles of 2 embryos and 189 embryos of 3 cycle. The two groups of embryo implantation rate, clinical pregnancy rate and multiple birth rate were compared. Results There was no significant difference in embryo implantation rate and clinical pregnancy rate between two embryo groups and three embryo groups (40.85% and 40.92%, 59.57% and 67.20%, P> 0.05). The rates of singleton pregnancies in 2 embryos were significantly higher than those in 3 embryos (64.29% and 40.16%, P <0.01), while the rates of triple pregnancies were significantly lower (1.43% and 22.83%, P <0.01) Rate difference was not significant (34.29% and 37.01%, P> 0.05). Conclusion For young women, the number of embryos transferred from 3 to 2 does not reduce the pregnancy rate of IVF. But significantly reduced the incidence of multiple pregnancies, especially high-order multiple pregnancy.