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为了确定口服脊髓灰质炎疫苗(OPV)再次免疫的必要性,许多作者首先把注意力集中在初次免疫后血清中和抗体持久性的观察。本文作者对捷克2～40岁具有不同免疫史的283人进行了为期6年(1970～1976)的观察。根据国内脊髓灰质炎病毒流行的主要型别和遗传稳定性差异,着重调查了Ⅰ、Ⅱ型中和抗体水平经初次免疫后的变动情况。将283名调查对象依原抗体滴度分成三组:A组具有三个型1∶128以上高抗体滴度;B组为Ⅰ型低抗体水平(1∶4或1∶8);C组为Ⅲ型低抗体水平。又根据免疫史不同进一步分为四个亚组:a亚组:近期OPV免疫的2～3岁小儿;b亚组:远期OPV免疫的5～10岁儿童;c亚组:11～24岁曾接种过Salk和Sabin疫苗的人;d亚组:未经免疫的30～40岁个体。原具有三个型高抗体滴度的2～3岁小儿,6年后普遍下降,Ⅰ型降低1个血清稀释度,Ⅲ型降低2.58个稀释度。原Ⅰ、Ⅲ型抗体滴度低的小儿,因被检人数太少,难以作出评价。Ⅰ、Ⅲ型抗体滴度高的5～10岁儿童,后来分别下降了0.91和2.18个稀释度。而原来Ⅰ、Ⅲ型抗体滴度低的儿童,则各上
In order to determine the need for re-immunization of oral poliovirus (OPV), many authors first focused their attention on serum neutralization and antibody persistence after primary immunization. The authors conducted a 6-year (1970-1976) observation of 283 Czech Republic patients aged 2 to 40 years with different immunizations. According to the main types and genetic stability differences of domestic poliovirus, the changes of neutralizing antibodies of type I and type II after primary immunization were investigated. 283 subjects were divided into three groups according to the original antibody titers: group A had three types of high antibody titers of 1:128 or above; group B was type I low antibody (1: 4 or 1: 8); group C Ⅲ type of low antibody levels. According to the different immunization history, it is further divided into four subgroups: a subgroup: 2 to 3 years old children with recent OPV immunity; b subgroup: 5 to 10 years old children with long-term OPV immunity; c subgroup: 11 to 24 years old Persons who have been vaccinated with Salk and Sabin; d Subgroup: Individuals 30 to 40 years old who have not been immunized. The children aged 2 to 3 who had three types of high antibody titers generally dropped after six years, with type I decreasing one serum dilution and type III decreasing 2.58 dilutions. The original type Ⅰ, Ⅲ antibody titers in children with low, due to the number of people were too small, it is difficult to make an assessment. Children aged 5 to 10 with high titers of type I and type III subsequently dropped by 0.91 and 2.18, respectively. The original type I, type III antibody titers children, then all on