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目的研究外周血中Th1/Th2型细胞因子IL-2、IL-4、IL-5及IL-6在药物流产过程中的表达变化。方法 Th1/Th2型细胞因子以IL-2、IL-4、IL-5及IL-6为代表,采用Q-PCR方法检测30例米非司酮早孕药物流产患者分别在用药前和孕囊排出后全血中IL-2、IL-4、IL-5及IL-6的表达水平。结果药物流产后外周血中的IL-4水平显著降低(P<0.05),其他细胞因子未见明显差异(P>0.05)。结论低水平的IL-4在药物流产过程中具有重要意义,外周血中Th1/Th2型细胞因子失衡是米非司酮导致流产的机制之一。
Objective To study the expression changes of Th1 / Th2 cytokines IL-2, IL-4, IL-5 and IL-6 in peripheral blood during medical abortion. Methods Th1 / Th2 type cytokines were detected by Q-PCR with IL-2, IL-4, IL-5 and IL-6 as the representatives. After the whole blood IL-2, IL-4, IL-5 and IL-6 expression levels. Results The level of IL-4 in peripheral blood was significantly decreased after medical abortion (P <0.05), but no significant difference was observed in other cytokines (P> 0.05). Conclusion Low level of IL-4 is of great significance in the medical abortion. The imbalance of Th1 / Th2 type cytokines in peripheral blood is one of the mechanisms of mifepristone induced abortion.