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目的:分析温肾促排汤联合炔雌醇环丙孕酮、二甲双胍对多囊卵巢综合征患者临床作用。方法:选择2013年10月至2015年5月诊断多囊卵巢综合征患者60例,随机分为中药组与对照组各30例。对照组患者给予炔雌醇环丙孕酮联合二甲双胍片治疗;中药组在炔雌醇环丙孕酮联合二甲双胍片治疗基础上给予加用温阳促排汤,每日一剂,分2次服用/日,疗程3个月。分别与治疗前、后采用检测血清黄体生成素(LH,IU/L)、促卵泡生成素(FSH,IU/L)、睾酮(T,nmol/L)、雌二醇(E2,pmol/L)水平,比较治疗前、后2组患者上述指标水平变化,以及治疗后患者排卵率以及妊娠率差异。结果:中药组治疗前与治疗后LH[(14.36±2.51)IU/L比(6.85±2.94)IU/L,t=4.962],FSH[(8.73±2.09)IU/L比(4.29±2.10)IU/L,t=3.945],T[(3.96±0.82)nmol/L比(1.73±0.68)nmol/L,t=3.265],E2[(156.90±23.64)pmol/L比(109.36±26.79)pmol/L,t=2.783];对照组治疗前与治疗后LH[(14.80±2.89)IU/L比(10.93±3.05)IU/L,t=2.062],FSH[(8.99±2.53)IU/L比(6.82±2.58)IU/L,t=2.584],T[(3.89±0.57)nmol/L比(2.58±0.91)nmol/L,t=2.579],E2[(158.93±26.39)pmol/L比(123.59±28.09)pmol/L,t=2.051],2组患者组内治疗前后比较差异有统计学意义(P<0.05)。治疗后,中药组血清LH、FSH、T、E2水平改善幅度优于对照组,2组患者组间比较差异有统计学意义(P<0.05)。治疗后,中药组排卵率[(23/30,76.67%)、妊娠率[(16/30,53.33%);对照组排卵率[(19/30,63.33%)、妊娠率[(10/30,33.33%),临床疗效明显改善,2组比较差异有统计学意义(P<0.05)。结论:温阳促排汤联合炔雌醇环丙孕酮、二甲双胍治疗可以明显降低患者高雄激素血症水平,提高多囊卵巢综合征患者排卵率及妊娠率。
OBJECTIVE: To analyze the clinical effect of Wenshen Jianpi Decoction combined with ethinyl estradiol cyproterone and metformin on patients with polycystic ovary syndrome. Methods: Sixty patients diagnosed with PCOS from October 2013 to May 2015 were randomly divided into two groups, 30 cases in each group. Patients in the control group were given ethinyl estradiol cyproterone combined with metformin tablets. The Chinese medicine group was treated with ethinylestradiol cyproterone combined with metformin tablets. / Day, treatment for 3 months. (LH, IU / L), follicle stimulating hormone (FSH, IU / L), testosterone (T, nmol / L) and estradiol (E2, pmol / L) were measured before and after treatment. ) Levels before and after treatment were compared before and after treatment, the changes of these indexes in the two groups of patients before and after treatment, as well as the difference of ovulation rate and pregnancy rate after treatment. Results: Compared with the control group, LH [(14.36 ± 2.51) IU / L (6.85 ± 2.94) IU / L, t = 4.962] and FSH (8.73 ± 2.09) IU / L ratio were 4.29 ± 2.10 before and after treatment The ratio of E2 [(156.90 ± 23.64) pmol / L vs (109.36 ± 26.79) IU / L, t = 3.945] and T [(3.96 ± 0.82) nmol / (14.80 ± 2.89) IU / L (10.93 ± 3.05) IU / L, t = 2.062] and FSH [(8.99 ± 2.53) IU / L [(6.82 ± 2.58) IU / L, t = 2.584], T [(3.89 ± 0.57) nmol / L ratio was 2.58 ± 0.91 nmol / L, t = 2.579] and E2 [(158.93 ± 26.39) pmol / L (123.59 ± 28.09) pmol / L, t = 2.051]. There was significant difference between the two groups before and after treatment (P <0.05). After treatment, the levels of serum LH, FSH, T and E2 in Chinese medicine group were better than those in control group. The difference between the two groups was statistically significant (P <0.05). After treatment, the ovulation rate in the control group [(23/30, 76.67%) and pregnancy rate [(16/30, 53.33% , 33.33%), the clinical curative effect improved obviously, the difference between the two groups was statistically significant (P <0.05). Conclusion: The combination of warming Yang and promoting soup with ethinyl estradiol, cyproterone and metformin can significantly reduce the level of hyperandrogenism and improve the ovulation rate and pregnancy rate in patients with polycystic ovary syndrome.