目的探讨高原冲击伤伤情和早期血液流变学的变化。方法用BST－Ⅰ型生物激波管和减压舱复制大鼠高原冲击伤模型。观察形态学和血液流变学的改变。结果形态学观察主要可见肺出血和肺水肿，伤后全血粘度明显升高，直至伤后6小时尚未恢复，血球压积在冲击伤暴露后有一过性升高。结论高原环境可使伤情加重和血液流变学改变 Objective To investigate the changes of impact injury and early hemorheology in high altitude. Methods The BST-Ⅰ shock tube and decompression chamber were used to replicate the rat model of high altitude impact injury. Morphological and hemorheological changes were observed. Results Morphological observation mainly showed pulmonary hemorrhage and pulmonary edema. Viscosity of whole blood was significantly increased after injury, and did not recover until 6 hours after injury. Hematocrit was transiently elevated after exposure to shock injury. Conclusion The plateau environment can aggravate the injury and change the hemorheology