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目的探讨光动力疗法对进展期消化道肿瘤的治疗效果。方法17例消化道进展期肿瘤患者,均进行内镜下光动力联合化疗,于治疗前及治疗后1、2、3、6、9、12个月进行内镜检查,并进行临床症状评定,随访生存时间,观察毒副作用。结果17例患者平均随访8.2个月,临床症状缓解率82.4%;内镜下完全应答率29.4%,部分应答率为52.9%;半年生存率76.5%,1年生存率47.1%,中位生存期为10个月。有1例出现皮肤光敏反应,1例术后1周出现大出血。结论光动力疗法可显著改善肿瘤患者的临床症状,是治疗进展期消化道肿瘤的又一有效手段。
Objective To investigate the therapeutic effect of photodynamic therapy on advanced gastrointestinal tumors. Methods Twenty-seven patients with advanced gastrointestinal cancer underwent endoscopic photodynamic therapy combined with chemotherapy. Endoscopic examination was performed before treatment, 1,2,3,6,9,12 months after treatment, and clinical symptoms were evaluated. Follow-up survival time, observe the side effects. Results The average follow-up of 17 patients was 8.2 months. The rate of clinical symptom relief was 82.4%. The complete response rate was 29.4% under endoscopy. The partial response rate was 52.9%. The half-year survival rate was 76.5%, and the 1-year survival rate was 47.1% For 10 months. One case had skin photoreaction, and one case had major bleeding one week after operation. Conclusion Photodynamic therapy can significantly improve the clinical symptoms of patients with cancer and is another effective means of treatment of advanced gastrointestinal cancer.