论文部分内容阅读
目的探讨糖调节受损(IGR)合并非酒精性脂肪肝(NAFLD)患者血清脂联素(APN)、瘦素(Leptin)及其比值(A/L)与胰岛素抵抗(IR)的相关性。方法选取经75gOGTT筛选的健康对照者30名,空腹血糖受损(IFG)合并NAFLD者32例、不合并者30例,IFG+糖耐量减低(IGT)合并NAFLD者32例、不合并者30例。IFG和IFG+IGT患者共60例组成IGR组,IFG+NAFLD和IFG+IGT+NAFLD患者共64例组成IGR+NAFLD组。测定人体参数、血糖、血脂、肝功、血清Ins、APN及Leptin水平,计算HOMA-IR及A/L。结果 (1)IGR+NAFLD组较IGR组APN、A/L降低,Leptin升高(P均<0.05)。(2)相关分析结果显示,APN和Leptin是IR的主要相关因素,IGR+NAFLD组相关系数大于IGR组;与IR的相关系数A/L大于HOMA-IR,IGR+NAFLD组大于IGR组。(3)多重线性回归分析结果显示,WHR、TG对A/L,WHR对HOMA-IR有显著影响;IGR+NAFLD组WHR、TG、LDL-C对A/L,WHR对HOMA-IR有显著影响。结论 (1)IGR患者有脂联素降低、瘦素升高、A/L降低及胰岛素抵抗,合并NAFLD时加重。(2)A/L可能为评价IR的指标之一。
Objective To investigate the relationship between serum adiponectin (APN), leptin and its ratio (A / L) and insulin resistance (IR) in patients with impaired glucose regulation (IGR) and nonalcoholic fatty liver disease (NAFLD). Methods Thirty healthy controls were screened by 75gOGTT. Among them, 32 cases were complicated with impaired fasting glucose (IFG) and NAFLD, 30 cases were unconformity, 32 cases were complicated with impaired glucose tolerance (IGT) and NAFLD. Sixty-four patients with IGR, IFG + NAFLD and IFG + IGT + NAFLD comprised 60 patients with IGR and NAFLD. Human parameters, blood glucose, blood lipids, liver function, serum Ins, APN and Leptin levels were measured and HOMA-IR and A / L were calculated. Results (1) The levels of APN, A / L and Leptin in IGR + NAFLD group were significantly lower than those in IGR group (all P <0.05). (2) Correlation analysis showed that APN and Leptin were the main related factors of IR. The correlation coefficient of IGR + NAFLD group was higher than that of IGR group. The correlation coefficient A / L with IR was higher than that of HOMA-IR group. (3) Multiple linear regression analysis showed that WHR and TG had significant effects on HOMA-IR in A / L and WHR groups; WHR, TG and LDL-C in IGR + NAFLD group were significantly higher than those in A / L and WHR groups influences. Conclusions (1) Patients with IGR have decreased adiponectin, elevated leptin, decreased A / L and insulin resistance, and aggravated with NAFLD. (2) A / L may be one of the indicators to evaluate IR.