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目的评价血清透明质酸(HA)、层粘连蛋白(LN)、Ⅳ型胶原(IV-C)、Ⅲ型前胶原(PC-III)水平与肝纤维化病变程度的相关性。方法应用放射免疫法对90例健康者,90例慢性肝病患者进行血清HA、LN、Ⅳ-C、PC-Ⅲ含量的测定,并进行对比分析,同时做肝组织活检,进行纤维化分期,对比不同分期四种指标的含量。结果①慢性肝病组4项指标均高于对照组,差异具有统计学意义(P<0.05);②随着肝脏损伤程度的严重程度,4项指标均逐渐增加,其中HA在早期即开始升高,Ⅳ-C在S0~S1期开始升高,S3~S4水平最高。结论HA、LN、Ⅳ-C、PCⅢ联合检测,对肝纤维化的诊断具有重要意义,其水平变化与肝脏损伤程度密切相关,其中HA和Ⅳ-C在肝纤维化的早期诊断可能具有重要意义。
Objective To evaluate the correlation between serum hyaluronic acid (HA), laminin (LN), type IV collagen (IV-C) and type III procollagen (PC-III) and the severity of liver fibrosis. Methods The serum levels of HA, LN, Ⅳ-C and PC-Ⅲ in 90 healthy people and 90 patients with chronic liver disease were measured by radioimmunoassay. The levels of serum HA, LN, Ⅳ-C and PC-Ⅲ were measured and compared. Different stages of four indicators of content. Results ① Four indicators of chronic liver disease group were higher than those of control group, the difference was statistically significant (P <0.05); ② With the severity of liver injury, four indicators were gradually increased, in which HA began to rise early , Ⅳ-C began to rise in the S0 ~ S1 phase, the highest level of S3 ~ S4. Conclusions Combined detection of HA, LN, Ⅳ-C and PCⅢ is of great significance for the diagnosis of liver fibrosis. The level of liver fibrosis is closely related to the degree of liver injury. HA and Ⅳ-C may be of great significance in the early diagnosis of liver fibrosis .