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目的:探讨不同程度羊水污染新生儿血GM-CSF、IL-6含量的临床诊断价值。方法:分别对84例出生时羊水不同程度污染新生儿血GM-CSF、IL-6含量进行检测,并与常规检查进行比较。结果:羊水污染组和无污染组新生儿炎症检测指标有统计学差异(P<0.05),GM-CSF含量在不同程度羊水污染组间有统计学差异(P<0.05)。结论:羊水污染新生儿的GM-CSF、IL-6含量对诊断感染的临床价值较白细胞数、中性粒细胞百分含量、血小板数、C反应蛋白高,尤其是羊水Ⅲ度污染的新生儿,羊水污染程度轻重与新生儿的GM-CSF含量具有相关性。新生儿科医生应关注羊水污染程度和GM-CSF、IL-6含量检测,结合具体情况采取干预措施。
Objective: To investigate the clinical value of serum GM-CSF and IL-6 in neonates with amniotic fluid contamination. Methods: The levels of serum GM-CSF and IL-6 in neonates with different degree of amniotic fluid contamination at birth were detected and compared with routine examination. Results: There was a significant difference in inflammatory markers between neonatal with amniotic fluid and non-polluted group (P <0.05). The levels of GM-CSF in amniotic fluid between groups were statistically different (P <0.05). CONCLUSION: The clinical value of GM-CSF and IL-6 in amniotic fluid polluted newborn infants is higher than that of white blood cell count, neutrophil percentage, platelet count and C-reactive protein, especially in third degree amniotic fluid , The degree of amniotic fluid pollution and neonatal GM-CSF content has relevance. Neonatologists should pay attention to the degree of amniotic fluid contamination and detection of GM-CSF and IL-6, and take interventions according to the specific conditions.