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目的观察百乐眠胶囊联合奥沙西泮治疗老年期失眠症的临床疗效及不良反应。方法选取2015年1~12月医院门诊收治的老年失眠症患者82例,随机分为治疗组和对照组各41例。治疗组予百乐眠胶囊及奥沙西泮治疗,对照组单用奥沙西泮治疗,疗程均为4周,分别于治疗前和治疗后第2、4周末采用匹兹堡睡眠质量指数量表和不反应量表进行评定。结果在治疗第2周末、第4周末2组PSQI评分均较治疗前降低,且差异有统计学意义(P<0.01);在治疗第4周末,2组PSQI各项评分低于治疗第2周末(P<0.05)。治疗组总有效率为92.7%明显优于对照组的87.8%,差异有统计学意义(P<0.05)。治疗组不良反应发生率4.9%明显低于对照组的9.8%,差异有统计学意义(P<0.01)。结论百乐眠胶囊联合奥沙西泮能够安全有效的改善老年人的失眠症状,且能够减少奥沙西泮的用药剂量,降低了不良反应,提高了患者的耐受性及依从性。
Objective To observe the clinical efficacy and adverse reactions of Bailemian capsule combined with oxazidophen in the treatment of senile insomnia. Methods Eighty-two elderly patients with insomnia admitted in hospital from January to December in 2015 were randomly divided into treatment group (41 cases) and control group (41 cases). The treatment group was treated with Bailemian capsule and oxazepam. The control group was treated with oxazepam alone. The course of treatment was 4 weeks. The Pittsburgh Sleep Quality Index Scale and the Pittsburgh Sleep Quality Index Scale were used before treatment and the second and fourth week after treatment, respectively No reaction scale assessment. Results At the end of the second week and the fourth week of treatment, the PSQI scores of the two groups were significantly lower than those before treatment (P <0.01). At the end of the fourth week, the PSQI scores of the two groups were lower than those of the second weekend (P <0.05). The total effective rate of the treatment group was 92.7%, which was significantly better than 87.8% of the control group, the difference was statistically significant (P <0.05). The incidence of adverse reactions in the treatment group was 4.9%, which was significantly lower than that in the control group (9.8%) (P <0.01). Conclusion Bailemian capsule combined with oxazepam can effectively and safely improve the symptoms of insomnia in the elderly, and can reduce the dose of oxazepam, reduce adverse reactions and improve patient tolerance and compliance.