0　引　　言系统性红斑狼疮 ( SLE)是一种全身性的自身免疫病 ,其血清学异常常表现为产生一系列特异的自身抗体 ,如抗 Sm、抗 ds- DNA、抗 U1- RNP等 ,其中可提取的核抗原 ( ENA)多肽抗体谱的出现在 SLE的发病机制中具有重要作用。近年来 ,国外有学者发现 SLE患者存在有较高水 0 Introduction SLE is a systemic autoimmune disease whose serological abnormalities often appear to produce a series of specific autoantibodies such as anti-Sm, anti-dsDNA, anti-U1-RNP, etc. Among them, systemic lupus erythematosus The appearance of extractable nuclear antigen (ENA) polypeptide antibody profiles plays an important role in the pathogenesis of SLE. In recent years, foreign scholars have found that there is a higher water SLE patients