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目的观察降钙素原指导ICU重症感染抗生素的应用效果。方法采用Meta分析法,检索中英文数据库中相关的临床试验,随机选取4篇相关随机对照试验(PCT)进行综合定量分析。结果共有386例随机对照患者纳入研究,Meta分析结果显示,PCT组患者的抗生素应用疗程短于对照组(P<0.05),但抗生素应用率、患者病死率与住ICU时间比较差异无统计学意义(P>0.05)。结论降钙素原指导ICU重症感染抗生素的应用效果满意,可明显缩短患者的抗生素应用疗程,值得临床推广。
Objective To observe the effect of procalcitonin on the antibiotics in intensive care unit (ICU). METHODS Meta-analysis was used to search related clinical trials in Chinese and English databases. Four related randomized controlled trials (PCTs) were randomly selected for comprehensive quantitative analysis. Results A total of 386 RCT patients were included in the study. The results of Meta analysis showed that the duration of antibiotic treatment was shorter in the PCT group than in the control group (P <0.05), but there was no significant difference in antibiotic application rate, patient mortality and ICU stay (P> 0.05). Conclusions The procalcitonin is effective in guiding the application of antibiotics in patients with ICU severe infection, which can significantly shorten the course of antibiotics applied to patients and is worthy of clinical promotion.