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目的:探讨丙种球蛋白联合注射用甲泼尼龙琥珀酸钠治疗重症手足口病(HFMD)患儿的临床效果。方法:选择我院2013年1月至2014年1月收治的重症HFMD患儿80例,按随机数字表法平均分为两组,研究组及对照组各40例。对照组患者在常规治疗基础上给予甲泼尼龙琥珀酸钠治疗,研究组患者给予丙种球蛋白联合注射用甲泼尼龙琥珀酸钠治疗,比较两组患儿治疗疗效,发热、疱疹、神经系统受累症状消退时间及住院时间。结果:研究组患儿治疗总有效率为97.5%,明显高于对照组87.5%,比较差异具有统计学意义(x2=3.85,P<0.05)。研究组患儿发热消退时间、疱疹消退时间、神经系统受累症状消退时间及住院时间均明显短于对照组,比较差异具有统计学意义(均P<0.05)。结论:丙种球蛋白联合注射用甲泼尼龙琥珀酸钠治疗重症HFMD患儿疗效显著,可有效改善患儿临床症状,值得临床推广应用。
Objective: To investigate the clinical effect of gamma globulin combined with methylprednisolone succinate in the treatment of severe hand-foot-mouth disease (HFMD) in children. Methods: Eighty children with severe HFMD admitted to our hospital from January 2013 to January 2014 were randomly divided into two groups according to the random number table method, 40 cases in study group and control group. Patients in the control group were treated with methylprednisolone sodium succinate on the basis of routine treatment. Patients in the study group were given gamma globulin combined with methylprednisolone sodium succinate for treatment. The curative effect, fever, herpes and nervous system involvement were compared between the two groups Symptom regression time and hospital stay. Results: The total effective rate in treatment group was 97.5%, which was significantly higher than that in control group (87.5%), the difference was statistically significant (x2 = 3.85, P <0.05). Study group children fever subsided time, herpes subsided time, symptoms of neurological regression and hospitalization time were significantly shorter than the control group, the difference was statistically significant (P <0.05). Conclusion: Gamma globulin combined with methylprednisolone sodium succinate in treatment of severe HFMD children with significant effect, which can effectively improve the clinical symptoms of children, it is worthy of clinical application.