4-Amino-5-pyridin-4-yl-s-triazole-3-thiol (1) was sequentally reacted with 3-chloro-1-phenylpropan-1-one to afford 3-(4-amino-5-pyridin-4-yl-s-triazole-3-sulfanyl)-1-phenylpropan-1-one (2) followed by oximation with hydroxylamine hydrochloride and etherification with 5-aryl-[13,4]oxadiazole-2-chloromethanes to the corresponding oxime (3) and oxime-ethers (4a-e),respectively. The condensation of compounds 4 with salicylaldehyde gave the title compounds (5a-e). The antibacterial activity in vitro against Gram-postive (G+) and Gram negative (G-)bacteria was primarily evaluated.