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目的:前瞻性研究代谢综合征(MS)与心血管事件发病风险的关系。方法:研究对象来源于中国医科大学附属第一医院,从体检确诊为MS人群中随机抽取300例,2006年～2011年连续随访5年。结果:270例进入本研究,其中男227例,女43例,年龄(56.23±18.15)岁。年龄标化后5年间心血管事件累积发病率为9.88%。基线高敏C反应蛋白(hsCRP)水平作4分层,Logistic回归分析显示:男女两性心血管事件的累积发病率均有随hsCRP水平升高而逐渐增加的趋势(P<0.01),调整基线年龄、高血压、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯、血糖(FBG/PBG)、吸烟和腹部肥胖后,男女两性中hsCRP≥3mg/L者发生心血管事件危险分别是hsCRP<1mg/L者的1.98倍(95%CI:1.15～5.77)和1.95倍(95%CI:1.13～5.39),P<0.01。结论:基线高敏C反应蛋白水平是代谢综合征人群发生心血管事件的独立预测因素,提示慢性炎症在代谢综合征人群心血管事件发生的病理过程中发挥重要作用。
Objective: To prospectively study the relationship between metabolic syndrome (MS) and the risk of cardiovascular events. Methods: The subjects were from the First Affiliated Hospital of China Medical University. 300 cases were randomly selected from the MS patients diagnosed by physical examination and were followed up for 5 years continuously from 2006 to 2011. Results: 270 patients entered the study, including 227 males and 43 females, with a mean age of 56.23 ± 18.15 years. The cumulative incidence of cardiovascular events was 9.88% after 5 years of standardization. Logistic regression analysis showed that the cumulative incidence of cardiovascular events in both sexes both increased gradually with the increase of hsCRP level (P <0.01), and adjusted the baseline age, HcCRP ≥ 3mg / L in men and women with cardiovascular risk after high blood pressure, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, blood glucose (FBG / PBG), smoking and abdominal obesity were hsCRP < 1.95-fold (95% CI: 1.15-5.77) and 1.95-fold (95% CI: 1.13-5.39), P <0.01 for 1 mg / L. CONCLUSION: Baseline high-sensitivity C-reactive protein is an independent predictor of cardiovascular events in people with metabolic syndrome, suggesting that chronic inflammation plays an important role in the pathogenesis of cardiovascular events in people with metabolic syndrome.