例1,王某,女,37岁。鼻出血30年,月经量多20年。用止血药物无效,输血后即止血。患者贫血貌,皮肤、粘膜无出血,脾肋下1.5cm。白细胞4.8×10~9/L,血红蛋白40g/L,血小板100×10~9/L。出凝血象检查见附表。经输全血1000ml(3次),好转出院。例2,王某,男,30岁(例1之三弟)。4岁开始鼻衄,伴齿龈出血,乏力,肘、肩、膝关节不定位肿痛,活动受限,1974年确诊为因子Ⅶ缺乏症。右肘和左踝关节肿大,压痛,双下肢有大小不等 Example 1, Wang, female, 37 years old. 30 years of epistaxis, menstrual flow more than 20 years. Hemostatic drugs used to stop bleeding after transfusion. Patients with anemia appearance, skin, mucous membrane without bleeding, spleen ribs 1.5cm. Leukocytes 4.8 × 10 ~ 9 / L, hemoglobin 40g / L, platelets 100 × 10 ~ 9 / L. A coagulation check see Schedule. Transfusion of whole blood 1000ml (3 times), improved discharged. Example 2, Wang, male, 30 years old (Example 1 third brother). 4 years old begins epistaxis, with bleeding gums, fatigue, elbow, shoulder, knee pain is not positioning and swelling, limited mobility, 1974 was diagnosed as factor Ⅶ deficiency. Right elbow and left ankle joint swelling, tenderness, both lower extremities have different sizes