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目的:探讨阴茎癌患者年龄和腹股沟淋巴结转移概率的关系。方法:我们回顾性分析110例腹股沟淋巴结临床阴性的阴茎鳞状细胞癌患者。通过局部加权回归散点平滑法(LOWESS)分析年龄和腹股沟淋巴结转移概率的关系。根据欧洲泌尿外科阴茎癌指南,将患者分为不同的转移风险组,随后比较不同转移风险组下各个年龄段的淋巴结转移概率。结果:本组患者中位年龄为54岁,最小者20岁,最大者75岁。淋巴结转移的概率大致呈现抛物线的形状:在<40和>60岁时较高,40～60岁时较为稳定。在淋巴结转移风险中危组和高危组,<40岁和>60岁组的淋巴结转移概率均高于40～60岁组。结论:阴茎癌的淋巴结转移概率随年龄变化而呈现<40岁和>60岁组增高的趋势,进一步的研究需要揭示不同年龄段肿瘤的特定分子生物学改变。
Objective: To investigate the relationship between the age of patients with penile cancer and the probability of inguinal lymph node metastasis. METHODS: We retrospectively analyzed 110 patients with clinically negative penile squamous cell carcinoma of the inguinal lymph nodes. The relationship between age and the probability of inguinal lymph node metastasis was analyzed by the LOWESS method. Patients were divided into different metastatic risk groups according to European Urology Guideline for Penile Cancer and subsequently the probability of lymph node metastases at all ages under different metastatic risk groups was compared. Results: The median age of patients in this group was 54 years old, the youngest was 20 years old and the oldest was 75 years old. The probability of lymph node metastases is roughly parabolic: higher at <40 and> 60 years and more stable at 40-60 years. At the risk of lymph node metastasis, the probability of lymph node metastasis was significantly higher in the group at the age of 40 to 60 years than in those at the age of 40 and 60 years. CONCLUSIONS: The probability of lymph node metastasis of penile cancer shows an increasing tendency with age in <40 years and> 60 years. Further research needs to reveal specific molecular biological changes in tumors of different ages.