【摘 要】
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Systemic JIA (SJIA) is one subtype of juvenile idiopathic arthritis (JIA) that is a leading cause of short-term and long-term disability in children [1].Althoug
【机 构】
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Department of Pediatrics, Qilu Hospital, Shandong University, Jinan 250012, China“,”Division of Nurs
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Systemic JIA (SJIA) is one subtype of juvenile idiopathic arthritis (JIA) that is a leading cause of short-term and long-term disability in children [1].Although SJIA represents only 10％-20％ of all cases of JIA,it accounts for more than two-thirds of the mortality associated with this condition [2].The etiology and pathogenesis of SJIA remain unknown.Further understanding of SJIA pathogenesis may facilitate new therapeutic approaches.Interleukin-18 (IL-18) was originally identified as an interferon gamma (IFN)-γ-inducing factor,and IL-18 can induce INF-γ production by splenocytes,hepatic lymphocytes,and type 1T helper (Thl) cell clones [3].IL-18 levels have been shown to be abnormal in some inflammatory diseases and in autoimmune diseases.IL-18 expression has been reported to be up-regulated in lupus nephritis (LN),type 1 diabetes,and other autoimmune diseases [4].
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